Detailed Mefloquine dosage information for adults and children. Includes dosages for Malaria Prophylaxis and Malaria; plus renal, liver and dialysis adjustments. mefloquine per week starting at least 2 weeks before traveling to the area where malaria transmission. and for 4 consecutive weeks after leaving. The weekly dosage for adults is 228mg base (250mg salt). Your doctor will have calculated the correct weekly dose for your child based on the child’s weight. The child’s dose should not exceed the adult dose of 228mg base (250mg salt) per week. Mefloquine treatment is well tolerated in infants (5-12 kg) but vomiting is a problem at high doses. This led to the use of a split dose regimen with 15 mg/kg initially, followed 12 hours later by 10 mg/kg. Mefloquine 125 mg has been used as intermittent preventive treatment (IPT) and was found to be efficacious in reducing episodes of malaria in a moderate-transmission setting but vomiting. How to use Mefloquine HCL. Read the Medication Guide provided by your pharmacist before you start taking mefloquine and each time you get a refill. Results. Chemoprophylaxis data: Two studies with a total of 170 children were found. A simulated mefloquine plasma profile showed that doses to achieve protective chemoprophylaxis blood concentration of mefloquine of approximately 620 ng/mL (or 1.67 μmol/L) in children should be at least 5 mg/kg. LARIAM® (mefloquine hydrochloride) Tablets. DESCRIPTION. Lariam (mefloquine hydrochloride) is an antimalarial agent available as 250-mg tablets of mefloquine hydrochloride (equivalent to 228.0 mg of the free base) for oral administration. Mefloquine may be crushed and put in water, milk, or juice to make it easier to take. For patients taking mefloquine to prevent the symptoms of malaria: Your doctor will want you to start taking this medicine one week before you travel to an area where there is a chance of getting malaria. Mefloquine is a medicine used to treat malaria, a disease caused by parasites. This medicine works by interfering with the growth of parasites in the red blood cells of the human body. Very small amounts of mefloquine are excreted in breastmilk; the amount of drug is not sufficient to harm the infant nor is the quantity sufficient to protect the child from malaria. Breastfeeding infants should receive the recommended dosages of mefloquine.[1] Mefloquine official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.